Harpagoside inhibits pro-inflammatory mediators (e.g. TNF-α, COX-2), reducing joint inflammation and oxidative stress. It also exerts mild analgesic effects and stimulates bile secretion via its bitter principles
Used in osteoarthritis, rheumatoid arthritis, tendonitis, lower back pain, and general inflammatory conditions affecting the joints and muscles.
Indigenous to Southern Africa, Devil’s Claw was traditionally used for fevers, digestive complaints, joint pain, and wound healing.
Commonly used as dried root decoction, capsule, or tincture. Standardised extracts are often used in clinical trials.
Gallstones, gastric or duodenal ulcers due to bitter stimulation; monitor blood pressure in hypertensive patients
May interact with anticoagulants, NSAIDs, and antidiabetic medications (monitor blood sugar).
