Pentacyclic alkaloids stimulate immune surveillance and modulate TNF-alpha and IL-1 levels, reducing inflammatory signalling. Quinovic acid glycosides show antiviral properties. Proanthocyanidins protect tissue from oxidative damage.
Used in rheumatoid arthritis, osteoarthritis, Lyme disease, chronic fatigue, viral infections, digestive inflammation (IBD), and cancer adjunct protocols.
Used by Asháninka and other Amazonian tribes for wound healing, gastrointestinal inflammation, and immune support. Traditionally prepared as a decoction from the inner bark.
Commonly used as tincture, capsule, or decoction. Only sustainably harvested inner bark should be used.
Avoid in organ transplant recipients and those using immunosuppressive drugs. Use cautiously in autoimmune diseases unless practitioner-guided.
May interact with immunosuppressants, anticoagulants, or blood pressure medication
