Parthenolide inhibits prostaglandin synthesis and NF-κB activation, modulating inflammation and platelet aggregation. It also impacts serotonin release, a key trigger in vascular migraine pathways.
Primarily used for migraine prophylaxis, menstrual headaches, neuralgic pain, and inflammatory vascular conditions. Also used for arthritis and chronic inflammatory states.
Traditionally used to reduce fevers (hence the name), relieve headaches, calm nervous tension, and regulate menstruation.
Most effective as a fresh plant extract or freeze-dried capsules. Also used in teas and tinctures, though bitterness is strong.
Allergy to Asteraceae family. Avoid in pregnancy (uterine stimulant).
May potentiate anticoagulants and antiplatelet drugs. Avoid with NSAIDs unless supervised.
